Tunesi Simone

Nato a Legnano il 13/8/88, laureato in Medicina nel 2014 presso l’Università degli Studi dell’Insubria e specializzatosi nel 2019 in Malattie infettive e tropicali.

Dopo diverse esperienze lavorative in Francia e in Italia, attualmente lavora presso l’UO Malattie infettive dell’Azienda ospedaliero-universitaria di Alessandria.

Il dott. Tunesi si occupa quotidianamente di patologie infettive di diversi organi e distretti. Tra le varie, vanta esperienza nella gestione di infezioni urinarie, della cute e degli annessi cutanei, dell’osso, delle vertebre, nonché di HIV, epatiti e malattie a trasmissione sessuale. Al suo attivo riporta inoltre esperienze nella medicina dei viaggi.

Il suo principale ambito di attività è quello delle infezioni del tratto respiratorio e dei polmoni. È responsabile dell’Ambulatorio tubercolosi e dell’Ambulatorio micobatteri non tubercolari e bronchiectasie presso la sua Azienda ospedaliera di afferenza.

Il suo curriculum vanta diverse esperienze formative e didattiche, anche all’estero. È attualmente membro del direttivo di TBnet, società scientifica europea focalizzata sulla tubercolosi, e docente a contratto di un modulo didattico di Igiene presso il Corso di Laurea in infermieristica dell’Università di Torino.

WORK EXPERIENCE

[ 03/2022 – Current ] Physician
AOU SS Antonio e Biagio e C. Arrigo, Infectious Diseases Unit
City: Alessandria | Country: Italy

[ 09/2023 – Current ] ID Consultant
Cantiello e Gaeta Penitentiary
City: Alessandria | Country: Italy

[ 08/2024 – Current ] Physician and ID Consultant
Coop Oltremare – Refugee Reception Center
City: San Salvatore Monferrato | Country: Italy

[ 11/2020 – 03/2022 ] Physician
ASST Valle Olona – Presidio Ospedaliero di Busto Arsizio, Infectious Diseases Unit
City: Busto Arsizio | Country: Italy

[ 11/2019 – 10/2020 ] Chef de Clinique – Assistant des Hôpitaux
Université Sorbonne Paris Nord – Hôpital Jean Verdier, Service de Médecine
Interne
City: Bondy | Country: France

EDUCATION AND TRAINING

[ 11/2015 – 10/2019 ] Residency in Infectious Diseases and Tropical Medicine
Università degli Studi di Genova – Ospedale Policlinico San Martino
City: Genova | Country: Italy | | Thesis: Tubeculose résistante à l’Isoniazide: étude
cas-témoin auprès d’un centre de référence français
Tuberculosis: diagnosis, treatment and follow up;
Spondylodiscitis: definition of an internal flowchart; databasing;
Tropical medicine: microscope use; definition of an internal diagnostic flowchart
about urinary schistostomiasis; databasing;
Long-acting antibiotics (Dalbavancin): implementation of use, databasing.

[ 09/2018 – 02/2019 ] Stage
Sanatorium – Centre Hospitalier de Bligny
City: Briis-sous-Forges | Country: France |
Clinical management of patients affected by MDT/XDR TB;
National French Reference Centre of Mycobacteria: participant to monthly
meetings;
Research projects about INH R TB and DAAs and second line TB drugs
coadministration.

[ 12/2017 – 02/2018 ] Stage
Centre de Santé
City: Diofior | Country: Senegal |
Collaboration between Residency School and Stop TB Italia NGO:
Clinical and laboratory activities in a peripheral rural health centre;
Tuberculosis: training in microscope and molecular (GeneXpert) diagnosis;
Screening in peripheral areas.

[09/2008 – 07/2014 ] University Diploma in Medicine
Università degli Studi dell’Insubria
City: Varese | Country: Italy | | Thesis: TB Consilium: un’esperienza di gestione e
monitoraggio della Tubercolosi in Europa
Besides curricular activities:
• Student Representative at: Medicine Course Council; Surgical and Morphological
Sciences Department Council; School Council (2013-2015);
• Local Exchange Officer – IFMSA-SISM, Varese Local Office (2013);
• Tutoring: Human normal Anatomy and Histology (2012-2013); Pharmacology
(2013-2014)

[ 09/2014 ] Stage
Hospital João de Barros Barreto, Universidade Federal do Pará – Nucleo de
Medicina Tropical
City: Belem | Country: Brazil

[ 07/2013 ] Stage
Universitätsklinikum – Station Paul Ehrlich
City: Bonn | Country: Germany

[ 11/2012 ] STEP – Sudan Tropical Exchange Project
City: Khartoum | Country: Sudan

LANGUAGE SKILLS

Mother toungue(s): Italian

Other language(s):

English
LISTENING B2 READING B2 WRITING B2
SPOKEN PRODUCTION B2 SPOKEN INTERACTION B2
French
LISTENING B2 READING B2 WRITING B2
SPOKEN PRODUCTION B2 SPOKEN INTERACTION B2
Portuguese
LISTENING A1 READING A1 WRITING A1
SPOKEN PRODUCTION A1 SPOKEN INTERACTION A1

PUBLICATIONS

[ 2017 ]
Role of Raltegravir in patients co-infected with HIV and HCV in the era of direct
antiviral agents
Taramasso L, Cenderello G, Riccardi N, Tunesi S, Di Biagio A.
New Microbiol. 2017 Oct;40(4):227-233. PMID: 28994443
Epub 2017 Oct 10.
[ 2018 ]
QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: a
Tuberculosis Network European Trialsgroup (TBnet) study
Guglielmetti L, Tiberi S, Burman M, Kunst H, Wejse C, Togonidze T, Bothamley G, Lange C;
TBnet; of the TBnet QTc survey.
Eur Respir J. 2018 Aug 16;52(2):1800537.
doi: 10.1183/13993003.00537-2018. Print 2018 Aug
Collaborator
[ 2020 ] Prescribing COVID-19 treatments: what we should never forget
Tunesi S, Bourgarit A.
J Infect. 2020 Aug;81(2):e85.
doi: 10.1016/j.jinf.2020.05.018. Epub 2020 May 13
[ 2021 ]
Corticosteroids in patients hospitalised for COVID-19 pneumonia who require
oxygen: observational comparative study using routine care data
Tran VT, Mahévas M, Bani-Sadr F, Robineau O, Perpoint T, Perrodeau E, Gallay L, Ravaud
P, Goehringer F, Lescure FX; COCORICO Collaborative Group.
Clin Microbiol Infect. 2021 Apr;27(4):603-610.
doi: 10.1016/j.cmi.2020.11.035. Epub 2020 Dec 8
Collaborator
[ 2021 ]
Fourteen-day survival among older adults with severe infection with severe acute
respiratory syndrome coronavirus 2 treated with corticosteroid: a cohort study
Gallay L, Tran VT, Perrodeau E, Vignier N, Mahevas M, Bisio F, Forestier E, Lescure FX;
COCO-OLD (Collaborative cOhort COrticoteroids for OLD patients with COvid-19) study
Group.
Clin Microbiol Infect. 2021 Aug;27(8):1145-1150.
doi: 10.1016/j.cmi.2021.03.021. Epub 2021 Apr 2
Collaborator
[ 2021 ]
Isoniazid-monoresistant tuberculosis in France: risk factors, treatment outcomes
and adverse events
Bachir M, Guglielmetti L, Tunesi S, Billard-Pomares T, Chiesi S, Jaffré J, Langris H, Pourcher
V, Schramm F, Lemaître N, Robert J; Isoniazid Resistance Group.
Int J Infect Dis. 2021 Jun;107:86-91.
doi: 10.1016/j.ijid.2021.03.093. Epub 2021 Apr 3
[ 2022 ]
Co-administration of treatment for rifampicin-resistant TB and chronic HCV
infection: A TBnet and ESGMYC study
Tunesi S, Dû DL, Gualano G, Millet JP, Skrahin A, Bothamley G, Casas X, Goletti D, Lange C,
Musso M, Palmieri F, Pourcher V, Rioux C, Skrahina A, Veziris N, Viatushka D, Jachym-
Fréchet M, Guglielmetti L; TBnet, The ESGMYC, and The French MDR-TB Group.
J Infect. 2022 Jun;84(6):834-872.
doi: 10.1016/j.jinf.2022.03.004. Epub 2022 Mar 7
[ 2022 ]
Molecular detection of isoniazid monoresistance improves tuberculosis treatment:
A retrospective cohort in France
Bachir M, Guglielmetti L, Tunesi S, Billard-Pomares T, Chiesi S, Jaffré J, Langris H, Pourcher
V, Schramm F, Lemaître N, Robert J; Isoniazid Resistance Group.
J Infect. 2022 Jul;85(1):24-30.
doi: 10.1016/j.jinf.2022.05.017. Epub 2022 May 20
[ 2022 ] T-SPOT. TB performed in lymphnodal tissue for the diagnosis of lymphadenitic TB
Tunesi S, Salah EB, Taybaly M, Litvinova E, Sellier N, Guihot A, Bourgarit A.
Int J Tuberc Lung Dis. 2022 Jul 1;26(7):688-690.
doi: 10.5588/ijtld.22.0055
[ 2022 ] Preventive therapy for contacts of drug-resistant tuberculosis
Kherabi Y, Tunesi S, Kay A, Guglielmetti L.
Pathogens. 2022 Oct 15;11(10):1189.
doi: 10.3390/pathogens11101189
[ 2023 ]
Increased linezolid plasma concentrations are associated with the development of
severe toxicity in MDR-TB treatment
Eimer J, Fréchet-Jachym M, Le Dû D, Caumes E, El-Helali N, Marigot-Outtandy D, Mechai F,
Peytavin G, Pourcher V, Rioux C, Yazdanpanah Y, Robert J, Guglielmetti L; LZDM group.
Clin Infect Dis. 2023 Feb 8;76(3):e947-e956.
doi: 10.1093/cid/ciac485
Collaborator
[ 2023 ]
Antimicrobial susceptibility of Mycobacterium abscessus and treatment of
pulmonary and extra-pulmonary infections
Tunesi S, Zelazny A, Awad Z, Mougari F, Buyck JM, Cambau E.
Clin Microbiol Infect. 2024 Jun;30(6):718-725.
doi: 10.1016/j.cmi.2023.09.019. Epub 2023 Oct 4
[ 2023 ]
Rare predicted loss-of-function variants of type I IFN immunity genes are associated
with life-threatening COVID-19
Matuozzo D et al
Genome Med. 2023 Apr 5;15(1):22.
doi: 10.1186/s13073-023-01173-8
Collaborator
[ 2024 ]
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2
infection
Marchal A et al
HGG Adv. 2024 Jul 18;5(3):100300.
doi: 10.1016/j.xhgg.2024.100300. Epub 2024 Apr 26
Collaborator

ATTENDED COURSES

28/09/2016 – 30/09/2016 ] Difficult-to-treat Mycobacterial infections
ESCMID Course – Brac, Croazia
[ 03/07/2017 – 07/07/2017 ] Laboratory Diagnosis of Parasites
London School of Tropical Medicine and Hygiene – London, UK
[ 25/10/2017 – 27/10/2017 ] Migration Medicine basic Course
SIMM /Caritas – Rome Course, Italia
[ 17/02/2018 – 24/02/2018 ] Training Course about Tuberculosis for Italian Cooperators
Stop Tb Italia – Diofior, Senegal
[ 30/06/2018 – 07/07/2018 ] 17th ESCMID Summer School
ESCMID Summer School – Paris, France
[ 15/05/2022 – 18/05/2022 ] TBnet Academy 2022
TBnet – Tbilisi, Georgia
[ 05/02/2024 – 08/02/2024 ] Corso di perfezionamento “Infezioni in Gravidanza”
Università di Firenze – Firenze, Italy
[ 20/05/2024 – 22/05/2024 ] Leprosy: Back to the Future
ESCMID Course – Bergen, Norway

PRESENTATIONS IN CONGRESSES/COURSES

Difficult to diagnose and life-threatening disseminated Mycobacterium tuberculosis
complex (MTC) infection in an immunocompetent migrant patient from Mali: a case
report.
Poster
SIMET Congress, 8 edition, Brescia, Italy
[ 22/02/2017 – 23/06/2017 ]
Spondilodiscite da Candida parapsilosis: diagnosi, terapia e gestione di un raro caso
di infezione fungina invasiva
Poster
DiTMO, 9 edition, Genova, Italy
[ 22/06/2017 – 23/06/2017 ]
Ruolo dei marcatori diagnostici indiretti nella diagnosi e nella gestione delle
infezioni fungine invasive: controversie e benefici
Poster
DiTMO, 9 edition, Genova, Italy
[ 28/09/2017 ]
Uso di dalbavancina (Xydalba©) nel trattamento delle infezioni cutanee: esperienza
della Clinica Malattie infettive dell’Ospedale Policlinico San Martino – Genova
Poster
SITA Congress, 8 edition, Milano, Italy
[ 22/11/2017 – 25/11/2017 ]
Possibile ruolo dei cannabinoidi nel trattamento della malnutrizione in fibrosi
cistica. Un caso clinico.
Poster
National Society of Cystic Fibrosis Congres, 13 edition, Napoli, Italy
[ 18/04/2019 ]
Co-administration of directly antiviral agents for HCV and second line MDR-TB
drugs: a multi- centre French case series
Co-administration of directly antiviral agents for HCV and second line MDR-TB drugs: a
multi- centre French case series
Oral presention
ECCMID, 29 edition, Amsterdam, The Netherlands
[ 09/09/2020 – 11/09/2020 ]
Faire face au COVID-19, mise en place de novo d’une unité mutualisée “COVID-19
non-réanimatoire”: organisation et résultats
Poster
21 Journée Nationale d’Infectologie, Poitiers
[ 09/09/2020 – 11/09/2020 ] Tuberculose résistante à l’isoniazide : expérience d’un centre de référence français
Poster
21 Journée Nationale d’Infectologie, Poitiers
[ 23/09/2020 – 25/09/2020 ] Setting up a new do-not-reanimate unit for COVID-19: organisation and results
E-poster presentation
ECCVID
[ 08/12/2020 – 11/12/2020 ]
Conversion d’un Service de Médicine interne en unité mutualisée dédiée à la
gestion de cas non réanimatoires de SARS-CoV-2 au sein d’un GH : expérience et
résultats
Poster
82 Congrès de la Société National Française de Médecine interne, Dijon
[ 10/03/2023 ] Spondilodisciti: Definizione e Patogenesi
Oral presentation
Le infezioni del rachide – Pollenzo, Italy
Description of an outbreak of Legionella pneumophila pneumonia in an urban
setting in Northern Italy during the COVID-19 pandemic
Oral presentation – Secondary Author
ECCMID, 31 edition, Wien, Austria
[ 15/12/2022 ] Terapia della MDR-TB
Oral presentation
Non è un paese per vecchi – 4 edition, Torino, Italy
[ 15/04/2023 – 18/04/2023 ]
Clinical improvement among 18 patients with severe central nervous system
tuberculosis by TNF-α inhibitor treatment adjunction: a retrospective observational
study
Oral presentation – Secondary Author
ECCMID, 33 edition, Copenhagen, Denmark
[ 21/05/2023 – 24/05/2023 ] Year in Review
Oral presentation
TBnet Academy 2023, Riga, Latvia
[ 14/06/2023 – 16/06/2023 ]
IO C(‘)ENTRO HIV Checkpoint in Genova, Italy: results of first year experience
towards future objectives and new operational strategies
Poster
ICAR (Italian Conference on AIDS and Antiviral Research), 15 edition, Bari, Italy
[ 26/05/2024 – 29/05/2024 ] TB and Viral Coinfections
Oral presentation
TBnet Academy 2024, Athens, Greece

NETWORKS AND MEMBERSHIPS

[ 2018 – Current ] TBnet Membership
[ 2023 – Current ] TBnet – Chair for Clinical TB area
• Management of TBnet studies approbation and monitoring
• Organization and chairing of TBnet webinars
• TBnet annual meeting organization
[ 06/05/2024 ] TBnet annual meeting
Member of the organizing committee
Presenter of 2 study proposal and 2 ongoing studies
[ 11/2021 ] TBnet webinar
Expert Panel Member – TB meningitis in children: what can we learn from European
multicentre studies by ptbnet?
[ 04/2022 ] TBnet webinar
Speaker – Hepatopaty and Tuberculosis
[ 04/2024 ] TBnet Webinar
Chair – Role of anti TNF for the treatment of paradoxical reactions during TB treatment